Stercoral sigmoid perforation after received carboplatin paclitaxel combination in advance stage non- small cell lung cancer: A case report

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	Stercoral sigmoid perforation after received carboplatin paclitaxel combination in advance stage non- small cell lung cancer: A case report

Vorraaud Kunnavuttivanich

Internal medicine department, Charoenkrung Pracharak Hospital, Department of medical services, Bangkok Metropolitan Administration (BMA)

Wasakorn Bunyayothin

Department of Pathology, Charoenkrung Pracharak Hospital, Department of medical services, Bangkok Metropolitan Administration (BMA)

Abstract

Combinations regimen of carboplatin with paclitaxel is one of mainstay regimen of palliative chemotherapy in patient diagnosed advance non-small cell lung cancer without driven mutation. Response to chemotherapy archive increasing of survival time and improve quality of life. This case report presents a female patient with newly diagnosed of advance non-small cell lung cancer recently received palliative chemotherapy carboplatin paclitaxel combination without significant adverse effect, 5 days after chemotherapy, she suffered from acute abdominal pain. Computer tomography scan was performed and found pneumoperitoneum without significant perforation site or peritoneal metastasis compared with previous scan. She underwent emergency exploratory laparotomy and found sigmoid colon perforation with fecal impact to perforated site. Sigmoidectomy with end colostomy was performed. Pathologic examination only found acute ulcer perforation without peritoneal metastasis. From case review, multiple preceding factors other than chemotherapy alone led to this complication.

How to Cite


	Kunnavuttivanich, V., & Bunyayothin, W. (2023). Stercoral sigmoid perforation after received carboplatin paclitaxel combination in advance stage non- small cell lung cancer: A case report. Journal of Charoenkrung Pracharak Hospital, 19(1), 75–88. Retrieved from https://he02.tci-thaijo.org/index.php/JCP/article/view/261087

Issue


	Vol. 19 No. 1 (2566): January - June 2023

Section


	Case Report

References

Carter J, Durfee J. A case of bowel perforation after neoadjuvant chemotherapy for advanced epithelial ovarian cancer. Gynecol Oncol [Internet]. 2007 [cited 2023 Apr 20]; 107: 586-9. Available from: http://dx.doi.org/10.1016/j.ygyno.2007.09.008.

Akinori S, Kenichi H, Takahiro K, Nobuaki M, Yoichi N, Ako H, et al. Intestinal perforation due to neutropenic enterocolitis in a patient treated with bevacizumab for ovarian cancer. Case Rep Oncol Med [Internet]. 2020 [cited 2023 Apr 20]; 2020; 2020: 7231358. Available from https://doi.org/ 10.1155/ 2020/7231358.

Owen S, Chasen M. Chemotherapy-induced small bowel perforation in a patient with extrapulmonary small-cell carcinoma of the small bowel. Curr Oncol [Internet]. 2008 [cited 2023 Apr 20]; 15: 298-301. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2601019.

Rose PG, Piver MS. Intestinal perforation secondary to paclitaxel. Gynecol Oncol [Internet]. 1995 [cited 2023 Apr 20]; 57: 270-2. Available from: http://dx.doi.org/10.1006/gyno.1995.1140.

de Haan D, van den Berg M. Colonic perforation secondary to taxol therapy: an unusual presentation. Onkologie [Internet]. 2006 [cited 2023 Apr 20] ;29: 541-2. Available from: http://dx.doi.org/ 10.1159/ 000096150.

Jayakody S, Wright DB, Chiong C, Liu M, Bouffler C, El-Khoury T. Rectal perforation following paclitaxel and carboplatin chemotherapy for advanced ovarian cancer: a case report and review of the literature. J Med Case Rep [Internet]. 2018 [cited 2023 Apr 20]; 12:221. Available from: http://dx.doi.org/10.1186/s13256-018-1759-z.

Shaikh DH, Baiomi A, Mehershahi S, Abbas H, Gongati S, Nayudu SK. Paclitaxel-induced bowel perforation: A rare cause of acute abdomen. Case Rep Gastroenterol [Internet]. 2020 [cited 2023 Apr 20]; 14: 687-94. Available from: http://dx.doi.org/10.1159/000510131.

Hapani S, Chu D, Wu S. Risk of gastrointestinal perforation in patients with cancer treated with bevacizumab: a meta-analysis. Lancet Oncol [Internet]. 2009 [cited 2023 Apr 20]; 10: 559-68. Available from: http://dx.doi.org/10.1016/S1470-2045(09)70112-3.

Samejima J, Adachi H, Kawamoto M, Saeki H, Kato N, Fujisawa J, et al. Rectal perforation in a patient treated with combination chemotherapy for lung cancer. Gan To Kagaku Ryoho [Internet]. 2009 [cited 2023 Mar 13]; 36: 301-4. Available from: https://pubmed.ncbi.nlm.nih.gov/19223751/.

Liu ZC, Wu D, Lan SJ, Wang DD. A case of multiple intestinal perforation secondary to paclitaxel and carboplatin combined chemotherapy for lung cancer. Zhonghua Zhong Liu Za Zhi [Internet]. 2019[cited 2023 Apr 20]; 41: 399-400. Available from: http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2019. 05.016.

Vaidya R, Habermann TM, Donohue JH, Ristow KM, Maurer MJ, Macon WR, et al. Bowel perforation in intestinal lymphoma: incidence and clinical features. Ann Oncol [Internet]. 2013 [cited 2023 Apr 20]; 24: 2439-43. Available from: http://dx.doi.org/10.1093/annonc/mdt188.

Mouchli MA, Meehan AM. Stercoral ulcer-associated perforation and chemotherapy.

Case Rep Oncol [Internet]. 2017 [cited 2023 Apr 20]; 10: 442-6. Available from: http://dx.doi.org/10.1159/000475756.

Takuro M, Yuhei S, Nobuhiko N, Hiroshi N, Soranobu N, Junichi K, et al. The incidence and the risk factors of bowel perforation due to chemotherapy in gastrointestinal diffuse large B cell lymphoma. Blood [Internet]. 2015 [cited 2023 Apr 20]; 126: 1515. Available from: https://doi.org/10.1182/ blood.V126.23.1515.1515.

Cihad T, Mazlum Y, Onder A, Bahaeddin T, Oguz B, Savas B, et al. Intestinal perforation that developed after chemotherapy in a patient diagnosed with non-Hodgkin lymphoma: a case report and review of literature. Int J Surg Case Rep [Internet]. 2017 [cited 2023 Apr 20]; 39: 321-3. Available from: https://doi.org/10.1016/j.ijscr.2017.08.058.

Jin Z, He D, Shen Y, Deng X, Wang Z. Small intestinal perforation during neoadjuvant chemotherapy for locally advanced rectal cancer: a case report [Internet]. Research Square; 2020 [cited 2023 Apr 20]. Available from: https://doi.org/10.21203/rs.3.rs-94555/v1.

Serpell JW, Nicholls RJ. Stercoral perforation of the colon. Br J Surg [Internet]. 1990 [cited 2023 Apr 20]; 77: 1325-9. Available from: http://dx.doi.org/10.1002/bjs.1800771204.

Chongxi R, Jinggang J, Yan S, Hongqiao W, Yan L, Fengshuo Y. Spontaneous colonic perforation in adults: Evaluation of a pooled case series. Sci Prog [Internet]. 2020 [cited 2023 Apr 20];103: 36850420945462. Available from: http://dx.doi.org/10.1177/0036850420945462.

Maurer CA, Renzulli P, Mazzucchelli L, Egger B, Seiler CA, Büchler MW. Use of accurate diagnostic criteria may increase incidence of stercoral perforation of the colon. Dis Colon Rectum [Internet]. 2000 [cited 2023 Apr 20]; 43: 991-8. Available from: http://dx.doi.org/10.1007/bf02237366.